Modulation of apoptosis by the widely distributed Bcl-2 homologueBak
Identifieur interne : 003360 ( Main/Exploration ); précédent : 003359; suivant : 003361Modulation of apoptosis by the widely distributed Bcl-2 homologueBak
Auteurs : Michael C. Kiefer [États-Unis] ; Matthew J. Brauer [États-Unis] ; Virginia C. Powers [États-Unis] ; Jason J. Wu [États-Unis] ; Samuil R. Umansky [États-Unis] ; L. David Tomei [États-Unis] ; Philip J. Barr [États-Unis]Source :
- Nature [ 0028-0836 ] ; 1995-04-20.
Abstract
MEMBERSof the Bcl-2 family of proteins are characterized by their ability to modulate cell death. Bcl-2 and some of its homologues inhibit apoptosis14, whereas other family members, such as Bax, will accelerate apoptosis under certain conditions5. Here we describe the identification and characterization of a complementary DNA that encodes a previously unknown Bcl-2 homologue designated Bak. Like Bax, the bak gene product primarily enhances apoptotic cell death following an appropriate stimulus. Unlike Bax, however, Bak can inhibit cell death in an EpsteinBarr-virus-transformed cell line. The widespread tissue distribution of Bak messenger RNA, including those containing long-lived, terminally differentiated cell types, suggests that cell-death-inducing activity is broadly distributed, and that tissue-specific modulation of apoptosis is controlled primarily by regulation of molecules that inhibit apoptosis.
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DOI: 10.1038/374736a0
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Bak</title><author><name sortKey="Kiefer, Michael C" sort="Kiefer, Michael C" uniqKey="Kiefer M" first="Michael C." last="Kiefer">Michael C. Kiefer</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>LXR Biotechnology Inc., 1401 Marina Way South, Richmond, California 94804</wicri:regionArea><wicri:noRegion>California 94804</wicri:noRegion></affiliation></author><author><name sortKey="Brauer, Matthew J" sort="Brauer, Matthew J" uniqKey="Brauer M" first="Matthew J." last="Brauer">Matthew J. Brauer</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>LXR Biotechnology Inc., 1401 Marina Way South, Richmond, California 94804</wicri:regionArea><wicri:noRegion>California 94804</wicri:noRegion></affiliation></author><author><name sortKey="Powers, Virginia C" sort="Powers, Virginia C" uniqKey="Powers V" first="Virginia C." last="Powers">Virginia C. Powers</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>LXR Biotechnology Inc., 1401 Marina Way South, Richmond, California 94804</wicri:regionArea><wicri:noRegion>California 94804</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Jason J" sort="Wu, Jason J" uniqKey="Wu J" first="Jason J." last="Wu">Jason J. Wu</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>LXR Biotechnology Inc., 1401 Marina Way South, Richmond, California 94804</wicri:regionArea><wicri:noRegion>California 94804</wicri:noRegion></affiliation></author><author><name sortKey="Umansky, Samuil R" sort="Umansky, Samuil R" uniqKey="Umansky S" first="Samuil R." last="Umansky">Samuil R. Umansky</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>LXR Biotechnology Inc., 1401 Marina Way South, Richmond, California 94804</wicri:regionArea><wicri:noRegion>California 94804</wicri:noRegion></affiliation></author><author><name sortKey="Tomei, L David" sort="Tomei, L David" uniqKey="Tomei L" first="L. David" last="Tomei">L. David Tomei</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>LXR Biotechnology Inc., 1401 Marina Way South, Richmond, California 94804</wicri:regionArea><wicri:noRegion>California 94804</wicri:noRegion></affiliation></author><author><name sortKey="Barr, Philip J" sort="Barr, Philip J" uniqKey="Barr P" first="Philip J." last="Barr">Philip J. Barr</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>LXR Biotechnology Inc., 1401 Marina Way South, Richmond, California 94804</wicri:regionArea><wicri:noRegion>California 94804</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Nature</title><imprint><publisher>Nature Publishing Group</publisher><date when="1995-04-20">1995-04-20</date><biblScope unit="vol">374</biblScope><biblScope unit="issue">6524</biblScope><biblScope unit="page" from="736">736</biblScope><biblScope unit="page" to="739">739</biblScope><date type="Copyright" when="2002">2002</date></imprint><idno type="ISSN">0028-0836</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0028-0836</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">MEMBERSof the Bcl-2 family of proteins are characterized by their ability to modulate cell death. Bcl-2 and some of its homologues inhibit apoptosis14, whereas other family members, such as Bax, will accelerate apoptosis under certain conditions5. Here we describe the identification and characterization of a complementary DNA that encodes a previously unknown Bcl-2 homologue designated Bak. Like Bax, the bak gene product primarily enhances apoptotic cell death following an appropriate stimulus. Unlike Bax, however, Bak can inhibit cell death in an EpsteinBarr-virus-transformed cell line. The widespread tissue distribution of Bak messenger RNA, including those containing long-lived, terminally differentiated cell types, suggests that cell-death-inducing activity is broadly distributed, and that tissue-specific modulation of apoptosis is controlled primarily by regulation of molecules that inhibit apoptosis.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Kiefer, Michael C" sort="Kiefer, Michael C" uniqKey="Kiefer M" first="Michael C." last="Kiefer">Michael C. Kiefer</name></noRegion><name sortKey="Barr, Philip J" sort="Barr, Philip J" uniqKey="Barr P" first="Philip J." last="Barr">Philip J. Barr</name><name sortKey="Brauer, Matthew J" sort="Brauer, Matthew J" uniqKey="Brauer M" first="Matthew J." last="Brauer">Matthew J. Brauer</name><name sortKey="Powers, Virginia C" sort="Powers, Virginia C" uniqKey="Powers V" first="Virginia C." last="Powers">Virginia C. 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